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Gamma Globulin Potentiation of Proteus Lipopolysaccharide Effect on Sarcoma 180^*

( Joseph and Helen Yeamans Levy Foundation Laboratories, Beth Israel Hospital, New York, N.Y.)

-Globulin in combination with Proteus vulgaris lipopolysaccharide inhibited tumor growth to a much greater extent than did the lipopolysaccharide alone. Combined treatment frequently caused regression and disappearance of the tumor.

The presence of a blood-tumor barrier was considered, as was also its alteration by lipopolysaccharide.

The nonspecificity of the combined -globulin-lipopolysaccharide effect on tumor growth is discussed.

^* Aided by the Dazian Foundation, The Saul Singer Foundation, and Grant H2670, National Institutes of Health, U.S. Public Health Service.

Received 8/ 7/61.