This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Teller, M. N. Search for Related Content PubMed PubMed Citation Articles by Teller, M. N.

Chemotherapy of Transplantable Human Tumors in the Rat

Division of Human Tumor Experimental Chemotherapy, Sloan-Kettering Institute for Cancer Research; Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University Medical College, New York, New York

The CCNSC Survey List of nineteen compounds was tested for growth-inhibiting activity against two transplantable human tumors growing subcutaneously in the x-irradiated and cortisone-treated rat. Actinomycin D, desacetylthiocolchicine, mitomycin C, n-methylformamide, cytoxan, actidione, and actinobolin were active against both the H.S.#1 and H.Ep.#3 tumors. Azaserine, triethylenemelamine, 6-mercaptopurine, and hydrocortisone acetate inhibited the growth of H.Ep.#3 but not that of H.S.#1. Urethane was active against H.S.#1, but not against H.Ep.#3. Amethopterin, HN₂, o-phenylenediamine, testosterone propionate, estradiol-17ß, miracil D, and 5-FUDR were inactive against both tumors.