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A New Approach to Differential Toxicity

Division of Experimental Chemotherapy, Sloan-Kettering Institute for Cancer Research, New York, New York and Department of Statistics, Roswell Park Memorial Institute, Buffalo, New York.

The need for better indices of toxicity differentials has long been recognized. An index is suggested here which has some important advantages — conceptual, technical, and operational — over the usual indices in the experimental situations where there is a linear relationship between tumor and host toxicity indices. The ability of this index to discriminate between the agents under test is shown by the results of an actual acreening experiment. The procedure looks as if it might be fruitful in other animal and clinical chemotherapy studies but further research is needed.