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The Effect of Deoxyadenosine 1-N-Oxide on Nucleic Acid Synthesis in Ascites Tumor Cells in Vitro

( Biochemical Section of the Fibiger Laboratory, Frd. d. V's Vej 11, Copenhagen, Denmark)

Deoxyadenosine 1-N-oxide has been found to have a specific and pronounced inhibiting effect on the synthesis of deoxyribonucleic acid in Ehrlich ascites tumor cells in vitro. The effect can under the experimental conditions used be abolished by the simultaneous addition of deoxyguanosine or of adenosine deaminase. Studies of the metabolism of deoxyadenosine 1-N-oxide in the Ehrlich ascites cells suggest that this compound is being reduced to deoxyadenosine, which is further converted partially to deoxyadenosine triphosphate and partially to deoxyinosine. The mechanism of inhibition of DNA synthesis by deoxyadenosine 1-N-oxide is discussed.

Received 5/22/61.