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A Transplantable Metastasizing Rhabdomyosarcoma (Mesenchymoma) in the W/Fu Rat^*

( Children's Cancer Research Foundation and the Department of Pathology, Harvard Medical School, at The Children's Hospital Medical Center, Boston, Massachusetts)

A rhabdomyosarcoma (mesenchymoma) occurring spontaneously in a young W/Fu female has been followed through 52 transplant generations, and its changes, both behavioral and morphologic, have been documented. There has been a progressive increase in malignancy, manifested by a less prolonged survival time, a shorter transplantation interval, more consistent transplantability, generalized metastases, and loss of characteristic morphology. This tumor, once specific for the W/Fu rat, now transcends strain borders, with 80–90 per cent transplantability in random-bred strains.

^* This investigation was supported in part by a research grant from the National Cancer Institute, NIH, USPHS #CY-3335.

Received 8/28/61.