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Studies of Fatty Acid Oxidation

IX. The Effects of Uncoupling Agents on the Oxidation of Fatty Acids by Transplantable Tumors

( McGill-Montreal General Hospital Research Institute, Montreal, P.Q., Canada)

Oxidation of decanoate-1-C¹⁴ and palmitate-1-C¹⁴ by slices or the ascitic forms of the Ehrlich carcinoma or Sarcoma 37 was relatively resistant to loss of adenosine triphosphate (ATP) produced by uncoupling agents, such as dinitrophenol (DNP) or the fatty acids themselves. However, the rate of incorporation of palmitate-1-C¹⁴ into phospholipides was decreased in the presence of DNP.

Mutually inhibitory effects among fatty acids occurred. Such effects were shown to be unlikely to result from isotopic dilution, competition among the fatty acids, or to uncoupling effects.

The observed inhibitions of the oxidation of decanoate-1-C¹⁴ and palmitate-1-C¹⁴ are interpreted in terms of the availability of acyl-CoA under various conditions and the effects of such acyl-CoA derivatives on the metabolism of fatty acids.

^* National Cancer Institute of Canada Associate Professor of Biochemistry, McGill University.

Received 9/25/61.