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The Phosphatides of Some Mouse Ascites Tumors and Rat Hepatomas^*

( Department of Biochemistry, University of California School of Medicine, San Francisco, California)

An investigation of the phosphatide characteristics of certain experimental tumors yielded the following results.

The enzyme system for methylating phosphatidylaminoethanol to phosphatidylcholine was found to be largely lacking in mouse ascites tumors and rat hepatomas. Only in the Morris hepatoma was it present in amounts greater than 10 per cent of that in normal liver. The total phosphatide content of the tumors was much less than that in liver, largely owing to a lower total lipide content. The proportions of principal phosphatide components were not greatly altered in the tumor. Where there was a change, it was in the direction of increased cephalin and decreased lecithin, as compared with the level in normal tissue. The fatty acid patterns of the tumor lipides were not significantly different from those of the lipides of liver and blood cells.

^* Aided by research grants from the American Cancer Society (T-88) and the Cancer Research Funds of the University of California.

Received 10/25/61.