This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Penn, N. W. Search for Related Content PubMed PubMed Citation Articles by Penn, N. W.

The Catabolism of Added Serum Albumin by a Mitochondrial Fraction from the Novikoff Hepatoma^*

( Departments of Biochemistry and Pathology, Albert Einstein College of Medicine, New York, N.Y.)

The presence of a coenzyme A-dependent system catabolizing added serum albumin has been demonstrated in a mitochondrial fraction from the transplantable Novikoff hepatoma. The tumor fraction possesses a level of activity comparable to that of normal rat liver mitochondrial preparations. The requirement for a preparative medium supplemented with nicotinamide or diphosphopyridine nucleotide for the isolation of an active mitochondrial fraction from tumor suggests either some deficiency or fragility in the particles, but the nature of this difference between hepatoma and liver is undermined.

^* These studies were supported by American Cancer Society Grant E-36, Public Health Service Grant RG-6633, and an Institutional Grant of the American Cancer Society.

Received 11/27/61.