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Experimental Studies of Factors Influencing Hepatic Metastases

X. Effect of Reticuloendothelial Stimulation^*

Edwin R. Fisher and Bernard Fisher

( Departments of Pathology and Surgery, University of Pittsburgh, Pittsburgh, Pa.)

Effective reticuloendothelial stimulation produced by Proferrin prior to the intraportal injection of Walker carcinoma cells resulted in a twofold increase in the number of animals exhibiting artificially induced metastases. In addition, the degree of hepatic involvement with tumor was approximately twice as great in these animals as in untreated controls. Although similar reticuloendothelial stimulation resulted from appropriate injections of BCG or endotoxin, no effect on the incidence or degree of hepatic involvement by these lesions was observed. All agents utilized were associated with alterations of serum glutamic oxalacetic and/or pyruvic transaminases, but only Proferrin produced sinusoidal compression due to swelling of Kupffer cells. This information, together with the previously noted augmentation of such lesions observed following reticuloendothelial blockade, is considered as strong evidence against a functional role of the reticuloendothelial system in the process of metastases in the experimental model utilized. It also indicates the significance of sinusoidal compression with resultant trapping of tumor cells within the liver in accounting for the effects noted.

^* Supported by grants from American Cancer Society and U.S.P.H.S. #C 5716.

Senior Research Fellow, U.S.P.H.S.

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