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Therapy of Heterotransplanted Choriocarcinoma^*

G. B. Pierce, Jr., A. R. Midgley, Jr. and E. L. Verney

( Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania)

Two choriocarcinomas of intrauterine origin were successfully heterotransplanted to cortisone-treated hamsters. The cells of these heterotransplanted choriocarcinomas had no greater sensitivity to methotrexate than did those from a heterotransplanted choriocarcinoma of testicular origin. Appearances suggestive of mesenchymogenesis from cytotrophoblast have been observed in the transplants of one of these tumors.

^* This work was supported in part by a grant (CY 3297) from the U.S.P.H.S. and by a grant (E-105) from the American Cancer Society, Inc.

Markle Scholar in Medical Science. Present address: Department of Pathology, The University of Michigan.

Sarah Mellon Scaife Fellow in Pathology. Present address: Department of Pathology, The University of Michigan.

Received 10/ 9/61.