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Studies on the Folic Acid Vitamins

VII. The Effects of Large Doses of Amethopterin in Patients with Cancer^*

( Oklahoma Medical Research Institute, Oklahoma City, Oklahoma; Department of Medicine, Georgetown University School of Medicine, and Georgetown University Medical Division [Cancer Chemotherapy], District of Columbia General Hospital, Washington, D.C.; and Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland)

Eighty-six patients with a variety of carcinomas and sarcomas have been given intravenous doses of amethopterin ranging from 2.5 to 10 mg/kg, repeated at intervals of 2–3 weeks. Doses of 5 mg/kg repeated at 2-week intervals were tolerated without undue toxicity by most of the patients, but larger doses usually produced prohibitive toxicity.

Objective evidence of tumor regression was noted in twenty of the 86 patients; nine of 43 with adenocarcinomas; nine of 27 with epidermoid carcinomas; and two of sixteen patients with other tumors.

Amethopterin used in the manner described may have some value in the management of patients with inoperable epidermoid carcinomas.

^* Supported in part by Grants (T118 and T119) from the American Cancer Society and (CY 4452, CYP 2824, and CYP 2823) from the U.S. Public Health Service.

Presented at the National Meeting of the American Association for Cancer Research, Philadelphia, Pennsylvania, April 12, 1958.

Received 12/14/61.