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Adrenotropic Activity of Mammo-somatotropic Tumors in Rats and Mice^*

I. Biologic Aspects

( Department of Pathology, Columbia University—Francis Delafield Hospital, New York, New York; and Boston Dispensary, Boston, Massachusetts)

Two transplantable rat mammo-somatotropic tumor strains, MtT.F4 and MtT.W5, were studied for AtH activity. MtT.F4 caused marked enlargement of adrenals, lymphopenia, thymic atrophy, and moderate enlargement of most viscera. MtT.W5 caused thymic enlargement, no lymphopenia, and moderate enlargement of most viscera, including the adrenals.

The findings suggested that both strains have growth-promoting and mammary gland-stimulating activities; MtT.F4 also has AtH activity, whereas MtT.W5 does not. Similar findings suggested that one mouse MtT (Strain 50) had AtH activity and another (Strain 48) did not. Adrenalectomy further increased body and tumor weights in the MtT.F4 hosts and had no such effect on MtT.W5 hosts. In normal rats, adrenalectomy tripled thymic weights; in MtT.F4 rats adrenalectomy not only prevented thymic involution but caused enlargement of this organ to 6 times normal, thus disclosing the somatotropic potency of its hormones. The increase in thymic weight, notably in adrenalectomized hosts, appears to be a good index of somatotropic activity and may serve as a growth hormone assay.

Enhancement of tumor growth, and StH and MtH activities of strain MtT.F4 by adrenalectomy support the view that one cell produces one hormone with the three activities (MtH, StH, and AtH).

^* This work has been supported by Grants C-6215 of the National Cancer Institute and AT 30-1-2891 of the Atomic Energy Commission.

Received 1/15/62.

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