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Changes in Proteolytic Enzyme Systems of Rat Tissues in Response to Heterologous Growth of Human Ovarian Tumors^*

( Graduate School of Arts and Science, New York University; and Department of Obstetrics and Gynecology, Columbia University, New York, New York)

Studies were made to determine the effect of heterologous growth of a human ovarian tumor on the proteolytic enzyme system of various tissues of weanling rats conditioned with cortisone and x-radiation. Conditioning per se had no effect on the activities of the tissues studied. Significant increases were observed in both aminopeptidase and cathepsin B activities of liver, kidney, and spleen of tumor-bearing animals. Trypsin inhibitors were found in lower concentration in tumor-bearing rats, thus exhibiting an inverse relationship to cathepsin B.

^* This work was done in the Department of Obstetrics and Gynecology, Columbia University, and supported by Grants P-261 and IN-4B, American Cancer Society.

Part of a thesis submitted by C. E. Blackwood to The Graduate School of Arts and Science, New York University, in partial fulfilment of the requirements for the degree of Doctor of Philosophy.

Received 4/12/62.