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The Effect of Ethionine on the Free Nucleotides in Rat Liver^*

( Istituto di Chimica Biologica dell'Universita di Urbino, Urbino, Italy)

In the rat liver, almost all free nucleotides underwent quantitative modification after dietetic treatment with ethionine (0.25 gm/100 gm of diet).

In particular, the free nucleotides of energetic type (ATP, UTP, GTP) were diminished, and this showed, under these experimental conditions, a decrease in the availability of high-energy bonds.

The cytidilic and uridylic nucleotides were also noticeably modified.

^* This investigation was supported by a grant from the Consiglio Nazionale delle Ricerche, Roma, Italy.

Received 1/29/62.