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The Collagen Content of Transplanted Tumors

( Tumor-Host Relations Section, Laboratory of Biochemistry, National Cancer Institute, Bethesda, Maryland)

The collagen content of eleven hepatomas, two fibrosarcomas, Walker carcinoma 256, and lymphosarcoma R-2788 was measured in rats and mice. All hepatomas studied contained more collagen than the normal liver. The amount of collagen formed in each tumor remained constant in all the transplant generations studied, regardless of the site of transplant or age of the tumor. In all tumors except Hepatoma 5123 the increase of collagen content was following in constant proportion the increase of the tumor mass. In this respect hepatomas differed from the regenerating liver. Hepatomas in rats and mice behaved in the same manner. The neoplastic cells appear to influence the collagen content of the tumor mass, and observations pointing to this conclusion are discussed.

Received 2/28/62.