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Serum Lactic Dehydrogenase and Glutamic-Oxaloacetic Transaminase Correlations with Measurements of Tumor Masses during Therapy^*

( Medicine Branch, National Cancer Institute, Bethesda, Md.)

Serum lactic dehydrogenase and serum glutamic oxaloacetic transaminase (SLDH and SGOT) and tumor size measurements were followed during therapy in a series of 91 cancer patients. Changes in SLDH levels usually indicated a corresponding change in tumor (P < .001). The agreement was not good in terminally ill patients, in whom tumor measurements were difficult and protein disturbances large. There was a lesser correlation between SGOT and tumor measurements (P < .05). SLDH seems to reflect the growth or regression of tumor in many patients with solid malignant neoplasms and may be useful in following their response to therapy.

^* Paper given in part at the Annual Meeting of the American Association for Cancer Research, Atlantic City, New Jersey, April, 1961.

Received 7/ 7/62.