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Studies with the Murine Leukemogenic Rauscher Virus

II. Chemotherapy of Virus-induced Lymphoid Leukemia

( Biochemical Pharmacology, Laboratory of Viral Oncology, and Pathologic Anatomy Branch, National Cancer Institute, Bethesda, Maryland)

Eight drugs were tested against the Rauscher virus-induced leukemia. In virus-inoculated mice a limited course of drug therapy was initiated after the mice had become leukemic. Netropsin, Melphalan, 6-mercaptopurine, and 5-fluorouracil produced a twofold increase in the survival time of leukemic animals. Cytoxan and Vincristine were moderately effective; p-anisaldehyde thiosemicarbazone and methylglyoxalbis-guanylhydrazone were only minimally effective. Inhibition of splenomegaly was observed in animals subjected to effective therapy.

^* Present address, Department of Pathology, Georgetown University Medical School, Washington, D.C.

Received 5/15/63.