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Histochemical Studies on Hydrolytic Enzyme Activities in Spontaneous Mammary Cancer of C3H Mouse

( Department of Oral Surgery, Osaka University Dental School, Kitaku, Osaka, and Shionogi Research Laboratory, Fukushimaku, Osaka, Japan)

Histochemical observations were carried out on various hydrolytic enzymes in the spontaneous mammary carcinoma of C3H-strain mice.

Alkaline phosphatase activity was observed in the luminal border of the tubular structure and in the periluminal surface, which showed a cystic dilatation in ducts and papillae. Capillaries in the stroma showed a high enzymatic activity. Acid phosphatase activity was moderate in the inner layer of large ductlike structure of neoplasms and rather slight in other parts. Esterase activity was variable in neoplastic epithelia. Activities for ß-glucuronidase and aminopeptidase were low in tumor cells. There was a complete lack of alkaline phosphatase activity in a medullary type of mammary cancer. The distribution of other hydrolytic enzymes was almost the same in all types of mammary carcinoma of C3H mouse.

Received 5/27/63.