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Transmissibility and Some Histopathology of a Spontaneously Originated Visceral Tumor in the Newt, Triturus pyrrhogaster^*

Sakae Inoue and Marcus Singer

( Department of Anatomy, School of Medicine and Developmental Biology Center, Western Reserve University, Cleveland, Ohio)

The characteristics of the spontaneous tumor of the liver found in Triturus pyrrhogaster are described in the present work, and it is shown that it can be transferred successfully to other urodeles, including T. viridescens, Hynobius lichenatus, and Amblystoma maculatum. The transfer can be made by direct implantation of a piece of fresh tumor into the peritoneal cavity. Frozen-dried specimens also induce a growth, as does the supernatant of a homogenized and centrifuged sample after repeated freezings and thawings. The supernatant can also induce an invasive and destructive growth when injected into the limb. Moreover, such growths metastasize to the liver.

In addition to involving the liver and spleen primarily, the tumor also is found in the kidney, gonad, and along the intestines. Ascites cells and fluid are also a sign of the neogrowth. The nature of the agent of tumor transmission has not been identified. However, the ensemble of information suggests that it is a microorganism.

^* Supported in part by grants from the American Cancer Society and the National Institutes of Health.

On leave from the Institute of Endocrinology, School of Medicine, Gunma University, Maebashi, Japan.

Received 6/17/63.