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Histochemical Observations of -Glycerophosphate Dehydrogenase Activity in Human Tumors

( Department of Oral Surgery and Histochemical Laboratory, Osaka University Dental School, Kitaku, Osaka, Japan)

A histochemical study was made of -glycerophosphate dehydrogenase in human tumors of 230 cases. Enzymatic activity was generally confined to the cell plasma in neoplastic cells, and stromal reaction was usually low or absent. The stainability for -glycerophosphate dehydrogenase was constant in normal tissue, whereas that of neoplastic cells was variable. Squamous-cell carcinomas showed varying degrees of enzymatic activity. Adenocarcinoma exhibited a moderate to strong activity, and 47 per cent of the stomach cancers seemed to be moderately reactive. Adenomas and fibroadenomas in the breast showed a moderate activity.

Activity and localization for -glycerophosphate dehydrogenase showed no characteristics, and no correlation was found with the degree of differentiation and malignancy.

Received 6/24/63.