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The Chromosomes of the 7,12-Dimethylbenz[a]anthracene-induced Tumors in Mastomys^*

( Biological Station, Roswell Park Memorial Institute, N.Y. State Department of Health, Springville, N.Y.)

The chromosome constitution of ten 7,12-dimethylbenz[a]anthracene-induced primary tumors and four of their early transplant lines in Mastomys was investigated. In contrast to the constant diploid chromosome number of 36 studied in the normal tissues of different organs, there were considerable numerical and structural variations in the cells of tumors. The tumors studied were individually different from one another. Four primary tumors had a "diploid" chromosome mode but with structural departures from the normal karyotype. One primary tumor had a mode of 36 plus one minute. The chromosome modes of the other five primary tumors were widely distributed from hypotetraploid to hypertetraploid.

Two transplanted Mastomys tumor lines maintained the same chromosome pattern as was observed in their primary tumors. In two other tumor lines, one shifted from a tetraploid mode to a hyperdiploid condition in the sixth transfer generation, the other from "diploid" to hypertetraploid in the first transplant generation.

^* This investigation was supported in part by a research grant from the United States Public Health Service, HE-02666-07.

Received 7/ 2/63.