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The Treatment of Anemia in the Tumor-bearing Hamster with Cortisone and Sodium Salicylate^*

Joseph D. Sherman and Gilbert H. Friedell

( Department of Pathology, Massachusetts Memorial Hospitals, Boston, Massachusetts)

Both cortisone acetate and sodium salicylate administered from the time of, or 1 week after, tumor transplantation inhibited the growth of a transplantable fibrosarcoma. Hamsters in these two treatment groups did not develop the anemia and splenomegaly which characteristically accompany the growth of this tumor in untreated animals. Their failure to develop anemia was attributed primarily to inhibition of tumor growth.

In anemic hamsters bearing large, advanced fibrosarcomas, however, the administration of cortisone prevented profound splenic changes and restored the hemoglobin to normal levels. Tumor necrosis was increased somewhat in these animals, but the abnormal splenic hemolysis produced by the necrotic tissue was thought to have been inhibited by the cortisone. Sodium salicylate was of transient therapeutic benefit in correcting the hemolytic anemia of the tumor-bearing hamster, and the morphology of the spleen was less abnormal than in the untreated tumor-bearing animal.

^* This work was supported in part by grant No. C-4959 from the National Institutes of Health, National Cancer Institute of the U.S. Public Health Service.

Present address: Blood Research Laboratory, Pratt Clinic-New England Center Hospital, Boston, Mass. Under tenure of USPHS Fellowship CF-3237.

Present address: Cancer Research Institute, New England Deaconess Hospital, Boston, Mass.

Received 5/31/62.