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Sarcoma Induced Remotely in Rats Fed 3-Methylcholanthrene^*

(The Ben May Laboratory for Cancer Research, University of Chicago, Chicago, Illinois)

Repeated feeding of large but tolerable doses of 3-methylcholanthrene plus the reiterated injections in a given area of solutions of sesame oil or sodium chloride, with or without dissolved hormones, frequently evoked a fibrosarcoma at the injection site and only in this location in female albino rats.

^* This study was aided by grants from the Jane Coffin Childs Memorial Fund for Medical Research and American Cancer Society, Inc.

Received 10/15/62.