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Pituitary Role in the Estrogen Dependency of Experimental Mammary Cancer^*

Abraham Sterental, J. Miguel Dominguez, Corinne Weissman and Olof H. Pearson

( Departments of Pathology and Medicine, Western Reserve University School of Medicine, Cleveland, Ohio)

Mammary tumors were induced in 50-day-old albino Sprague-Dawley rats by a single feeding of 20 mg. of 7,12-dimethylbenz[a]anthracene. Adrenalectomy-ovariectomy and hypophysectomy performed within 10–20 days after tumors were first detected resulted in tumor regression in all the animals. Estrogen administration reactivated tumor growth after adrenalectomy-ovariectomy but not after hypophysectomy. The estrogen unresponsiveness of tumors in hypophysectomized animals was not modified by thyroid and cortisone replacement therapy. These results indicate that the estrogen stimulation of this tumor is dependent upon the presence of the pituitary gland.

^* This work was supported by grants from the United States Public Health Service, National Institutes of Health, #Cy-5197 (C2), and from the American Cancer Society, Inc.

Present address: Instituto Nacional de Enfermedades Neoplasicas, Lima, Peru.

Damon Runyon Research Fellow.

Received 10/18/62.