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Growth of Normal and Rous Sarcoma Virus-infected Chick Embryo Cells in Rat Brains^*

( Variety Children's Research Foundation, Miami, and the Departments of Pathology and Microbiology, University of Miami School of Medicine, Coral Gables, Florida)

A comparison was made of the growth capacity in vivo of normal chick embryo cells and identical cells infected with Rous sarcoma virus. The latter cells grew more efficiently and developed into typical Rous sarcomas in the rat brain. This effect was noted even when the cells were allowed to remain in contact with virus for a short period of 15–90 minutes. More abundant growths were often obtained when the cells were exposed to virus for a longer period of time (2 days) prior to transplantation. The infected cells did not give any morphologic evidence of transformation by virus at the time they were implanted. Hemorrhage in many of the Rous tumors was a striking feature.

^* This work was supported principally by a U.S. Public Health Service Research Grant, C-4908, and in part by a U.S. Public Health Service Research Grant, C-0645, from the National Cancer Institute.

Received 9/ 4/62.