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Effects of Alcohol in Mouse Neoplasia

( Surgery Branch and the Biometry Branch, National Cancer Institute, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Maryland)

Mice survive indefinitely on a regimen of 20 per cent alcohol by volume in their water as their only source of fluid intake. This induces marked but reversible changes in liver fat appearance. Over a period of 15 months on the regimen no evidence of tumorigenesis was found. The alcohol regimen did not alter the growth or stimulate the metastatic spread of a transplanted tumor, nor did it interfere with the reduction in metastatic spread due to surgical removal of the tumor. It is concluded that, if alcohol plays a role in mouse neoplasia, it is one dependent on factors missing from the current experiments.

Received 9/27/62.

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