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The Cytotoxic Effects of Hemolytic Streptococci on Ascites Tumor Cells^*

( Division of Pathology, The Institute for Cancer Research, and Department of Microbiology, Temple University, School of Medicine and Oncologic Hospital, Philadelphia, Pennsylvania)

The effect of living hemolytic streptococci on ascites tumor cells (Sarcoma 37 and Krebs-2 carcinoma) was studied in vitro by phase microscopy and in vivo by implantation into mice. The effects produced by Streptococcus pyogenes strains were compared with those of Serratia marcescens, Sarcina lutea, and Streptococcus faecalis. Three of the eight streptococcal strains were highly effective against the tumor cells, resulting in reduced number of tumor "takes" and reduction of tumor sizes, whereas S. lutea, S. marcescens, and S. faecalis were only partially effective in damaging tumor cells after in vitro incubation. The cytological changes are recorded by phase photomicrography, and the histopathological findings of the tumor implantation sites are described.

^* This work was supported in part by Grant CY-2976-CY from the National Cancer Institute, National Institutes of Health, Public Health Service, and in part from a grant from the New York Cancer Research Institute, Inc.

Received 11/19/62.