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Action of Bacterial Polysaccharide on Tumors

III. Repeated Response of Sarcoma 37, in Tolerant Mice, to Serratia marcescens Endotoxin

( Laboratory of Chemical Pharmacology, National Cancer Institute, Bethesda, Maryland)

In the treatment of mice with Serratia marcescens polysaccharide, the pronounced tolerance induced by a single dose was surmounted when the subsequent doses were sufficiently increased. The overcoming of tolerance was observed in three phenomena: mortality of tumor-bearing mice; tumor-damaging potency of blood serum from treated mice; and repeated depression of tumor growth.

Received 1/10/63.