This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fisher, E. R. Articles by Fisher, B. Search for Related Content PubMed PubMed Citation Articles by Fisher, E. R. Articles by Fisher, B.

Experimental Studies of Factors Influencing the Development of Hepatic Metastases

XIII. Effect of Hepatic Trauma in Parabiotic Pairs^*

( Departments of Pathology and Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania)

The incidence and size of hepatic metastases in parabionts subjected to intraportal injection of Walker tumor cells were similar to those observed in single animals receiving comparable numbers of tumor cells regardless of whether the liver of the contralateral member was manipulated or not. Similarly, no enhancing or other effect on these hepatic tumors was encountered when partial hepatectomy was performed in the uninjected parabiont. On the other hand, metastases were found only in the livers of those uninjected parabionts subjected to hepatic manipulation. A few animals subjected to partial hepatectomy also exhibited hepatic metastases when partial hepatectomy was performed immediately after tumor cell injection in the contralateral member. This effect of manipulation was noted when parabiotic pairs were separated as early as 20 minutes after tumor cell injection, although the incidence and size of lesions in the manipulated livers were not as great as those noted when separation was performed at 3 days or 2 weeks. The incidence and size of pulmonary metastases were comparable in both parabiotic members in all instances. Manipulation of spleen or kidney failed to influence the incidence of metastases within these organs or the liver.

^* Supported by grants from the American Cancer Society and U.S.P.H.S.

Received 1/19/63.

This article has been cited by other articles:

				R. Demicheli, M. W. Retsky, W. J. M. Hrushesky, M. Baum, and I. D. Gukas The effects of surgery on tumor growth: a century of investigations Ann. Onc., June 10, 2008; (2008) mdn386v1. [Abstract] [Full Text] [PDF]