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Lymphoid Hyperplasia and Neoplasia Associated with a Mouse Pituitary Thyrotropic Tumor^*

Edith E. Sproul, Raul Grinberg and Sidney C. Werner

( Columbia College of Physicians and Surgeons and Frances Delafield Hospital, New York; and Roswell Park Memorial Institute, N.Y. State Department of Health, Buffalo, New York)

A transplanted autonomous responsive thyrotropic pituitary tumor, designated L24a, developed in an intact LAF₁ female mouse 13 months after inoculation of the L24 tumor. The latter is an autonomous thyroid-stimulating mouse pituitary tumor initiated by radiothyroidectomy and serially carried intramuscularly in the LAF₁ strain. Subsequent transplants of subline L24a were accompanied by hyperplasia and neoplasia of the reticuloendothelial system and by evidence of somatotropic hyperactivity. The greatest lymphoid-stimulatory effect appeared in radiothyroidectomized mice bearing the L24a tumor. Somatotropic effect was more apparent when the thyroid was intact. The control mice did not develop tissue lymphocytosis during this experiment. The factors which may have contributed to lymphoid stimulation were considered to be a high blood level of TSH, absence of the thyroid gland, the effects of I¹³¹ on lymph nodes and thymus, and possible adrenal gland hypoactivity. Growth hormone and ovarian hyperactivity may also have played a role. Thyrotropin is perhaps of greatest significance.

^* Supported by Contract SA-43ph-2402 Cancer Chemotherapy National Service Center, National Cancer Institute, United States Public Health; and New York City Department of Hospitals, N.Y. State Department of Health.

Present address: Roswell Park Memorial Institute, Buffalo, New York.

Received 3/29/63.