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The Effects of Triamcinolone Diacetate on Levels of 3-Methylcholanthrene in Rat Mammary Glands^*

( Department of Surgery, The University of Chicago School of Medicine, Chicago, Illinois)

The suppression of 3-methylcholanthrene (3-MC)-induced mammary carcinoma in the white rat produced by triamcinolone diacetate was investigated by the quantitative analysis of the localization of 3-MC in the mammary gland of rats receiving triamcinolone diacetate as compared with rats not receiving this steroid. The analysis shows that there is no difference in the uptake of 3-MC in rats receiving triamcinolone diacetate. Levels of 3-MC in the mammary gland increase in direct proportion to the quantity of carcinogen fed. A single oral dose (50 mg.) disappears from the breast in 15 days in normal as well as in triamcinolone-treated rats. The results indicate that the suppression of mammary carcinoma produced by triamcinolone diacetate cannot be explained by the altered uptake or clearance of carcinogen by the mammary gland.

^* This work was supported by grants from the Gladys Bowyer Foundation and Mr. Burr L. Robbins.

Received 11/12/62.

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