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A Mitomycin C-Resistant Jensen Rat Sarcoma: Chemotherapy Studies^*

Division of Experimental Chemotherapy, Sloan-Kettering Institute for Cancer Research, Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University, New York, New York

A total of 38 compounds and antibiotics were tested against a mitomycin C-resistant Jensen Rat Sarcoma. Seventeen alkylating agents and two folic acid antagonists, which were effective against the mitomycin C-sensitive Jensen rat sarcoma, were found to be relatively non-inhibitory against the mitomycin C-resistant Jensen rat sarcoma. Nineteen compounds which were inactive or slightly inhibitory against the mitomycin C-sensitive sarcoma were judged to be relatively inactive against the mitomycin C-resistant sarcoma.

^* This investigation was supported in part by a grant from the American Cancer Society and in part by contract SA-43-ph-2445, Cancer Chemotherapy National Service Center, National Cancer Institute, National Institutes of Health.

¹ Present address: College of Pharmacy, University of Tennessee, Memphis, Tennessee.