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Studies of Blood Group Antigens in Benign and Malignant Human Breast Tissue^*

Milton Tellem, Helen R. Plotkin and David R. Meranze

( Albert Einstein Medical Center, Southern Division, Philadelphia, Pennsylvania)

A series of benign and malignant breast tissues were studied by fluorescent antibody and hemagglutination inhibition for the presence of A, B, and D (Rh₀) blood group antigens. No differences were found between these two groups of tissues for any of these antigens. The benign or atypical tissue immediately adjacent to the malignant area more often showed the same loss or retention of antigen as the carcinoma. There was no correlation of the loss of blood group antigen in the primary cancer site with that of axillary lymph node metastasis. An absence of staining mixed with areas of specific staining was noted only in the malignant and adjacent tissue sections.

^* This investigation was supported by a grant (E-218) from the American Cancer Society, and a grant from the Strickler Fund, Albert Einstein Medical Center, Philadelphia.

Present address: Hahnemann Medical College and Hospital, Philadelphia, Pa.

Received 3/ 8/63.