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Electron Microscopic Study of the Passage A Mouse Leukemia Virus in Mammary Glands of Pregnant, Virus-injected, C3H(f) Mice^*

( Cancer Research Unit, Veterans Administration Hospital, Bronx, New York)

Ultrathin sections of mammary glands from four pregnant C3H(f) females with passage A virus-induced leukemia were examined with the electron microscope and revealed the presence of a considerable number of virus particles similar in appearance to those observed in other organs of leukemic mice. Particles often seemed continuous with the cell membrane of the mammary epithelium, apparently in the process of budding.

When mammary glands of five pregnant, virus-injected, but nonleukemic, C3H(f) females were examined, virus particles, generally in smaller quantities than in the leukemic mice, were found in three out of five mice examined.

No particles were observed in the mammary glands of three healthy pregnant and two lactating C3H(f) females that had not been given injections of the virus.

^* Aided in part by grants from the Damon Runyon Memorial Fund and the American Cancer Society.

Received 5/23/63.

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