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Reduction of Normal Muscle Antigens in Rat Tumors of Muscle Origin Induced by Intramuscular Injections of 20-Methylcholanthrene

( Laboratory of Cancer Cytology, Institute of Cytology of the Academy of Science of the USSR, Leningrad, Russia)

A study of primary rat tumors of muscle origin induced by intramuscular injections of 20-methylcholanthrene has shown that, after conversion to malignant cells, the synthesis of antigens specific for normal muscle tissue decreases. This process affects both the myofibrillar and the sarcoplasmic proteins; the decrease in actomyosin content in tumor tissue as compared with normal muscle tissue considerably exceeds the corresponding changes of sarcoplasmic proteins. The comparison of antigenic properties of some muscle tumors indicates the existence of antigenic differences which are apparently due to the fact that in different tumors disturbances of synthesis affect different antigens.

Evidence on the decrease of myofibrillar and sarcoplasmic proteins is in accord with modern views on the deletion of organospecific antigens from tumor cells (1, 12). According to present theories the antigenic deletion is based on quantitative changes in the synthesis of organospecific antigens.

Received 1/ 6/64.