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The Vascular Space of Growing Tumors

( Tumor Host Relations Section, Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland)

The volume of the vascular space was found to represent from 1.0 to 12.4 per cent of the tumor mass in a group of rat and mouse transplanted neoplasms. The estimate of the vascular space was based on an experimental model in which (a) high molecular weight dextran was allowed to remain in the vascular system for several hours, (b) the exclusive localization of the marker to the vascular space during this time period was ascertained by direct measurement of its concentration in the interstitial fluid, and (c) the uniformity of distribution throughout the tumor was established. This method seems to have general applicability to every type of transplantable neoplasm. The vascular space increased linearly with the tumor size when the neoplastic masses were small (4–12 gm.), but no prediction was possible for larger tumors. No correlation between the vascular space and the collagen content of tumors was found. However, in sublines developed from two tumors which showed different cell properties, the vascular space also differed, suggesting that the neoplastic cell population influences the formation of the neoplastic vascular system.

Received 4/27/64.

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