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Electron-microscopic Study of the Mouse Leukemia Virus (Gross), and of Tissues from Mice with Virus-induced Leukemia^*

( Cancer Research Unit, Veterans Administration Hospital, Bronx, New York)

Virus-like particles present in thymus, spleen, lymph node, bone marrow, lung, kidney, liver, salivary gland, and mammary gland of C3Hf mice with passage A virusinduced leukemia were examined with the electron microscope. The morphology, size, and location of budding particles, doughnut-type particles, cylindrical and multiple particles, and particles with nucleoids and with tail-like structures were studied. Budding of particles occurred from lymphoblasts, lymphocytes, monoblasts, monocytes, erythroblasts, developing eosinophils and neutrophils, plasma cells, reticular cells, megakaryocytes, and the epithelium of apparently normal mammary and salivary glands. Also observed were smaller doughnut-type particles present within the endoplasmic reticulum.

In addition, the appearance of leukemic tissues was described, including the infiltration of leukemic cells into lung, liver, and kidney, the presence of particles in vacuoles and inclusion bodies of phagocytic reticular cells and macrophages, and typical morphologic changes within the cell.

^* Aided in part by grants from the Damon Runyon Memorial Fund and the American Cancer Society.

Received 6/10/64.