This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Metcalf, D. Search for Related Content PubMed PubMed Citation Articles by Metcalf, D.

Thymus Grafts and Leukemogenesis^*

( Cancer Research Laboratory, Walter and Eliza Hall Institute, Royal Melbourne Hospital Post Office, Victoria, Australia)

Thymus grafts from high leukemia strain AKR mice increased the incidence of generalized lymphoid leukemia and reticulum-cell sarcoma in leukemia-resistant (AKR x C57BL)F₁ mice, particularly in female mice. Almost all the neoplasms were derived from F₁ host cells. Splenectomy did not alter the effects of thymus grafting. Urethan treatment shortened the latent period of leukemia and reticulum-cell sarcoma development in (AKR x C57BL)F₁ mice but had no additive effect to the effects of AKR thymus grafting. AKR thymus grafts did not increase leukemia incidence of shorten the latent period for leukemia development in leukemia-susceptible (AKR x C3H)F₁ mice.

^* This work was supported by the Carden Fellowship Fund of the Anti-Cancer Council of Victoria.

Received 6/15/64.