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Immunity to Spontaneous and Methylcholanthrene-induced Tumors in Inbred Mice

Richard S. Riggins^* and Yosef H. Pilch

( Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland)

Inbred C3H/HEN mice were shown to develop a specific immunity to a spontaneously arising adenocarcinoma as well as to a methylcholanthrene-induced fibrosarcoma when the tumors were allowed to grow temporarily in their hind limb. The resistance in the spontaneous carcinoma system was less than in the fibrosarcoma system. In each case the immunity produced was specific for the immunizing tumor, and no cross-immunity was observed. Animals challenged shortly after removal of their immunizing tumor and animals in which the immunizing tumor was not removed did not exhibit any resistance toward a second tumor transplant.

Whether other spontaneous mammary carcinomas and methylcholanthrene-induced sarcomas will behave similarly requires further investigation. The results reported in this paper may apply only to the specific tumors studied.

^* Present address: The Campbell Clinic, Memphis, Tenn.

Present address: Department of Surgery, Albert Einstein College of Medicine, Bronx, N. Y.

Received 7/10/64.