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Induction of Mitotic Synchrony by Intermittent Hyperthermia in the Walker 256 Rat Carcinoma^*

Robert J. Martin and Paul R. Schloerb

( Department of Surgery and the Surgical Research Laboratories, University of Kansas School of Medicine, Kansas City, Kansas)

Rats with the transplanted Walker 256 carcinoma were subjected to intermittent body hyperthermia (average, 40.5° C.) by infrared lamp heating for 15 minutes every 3, 6, or 12 hours. Tumor mitoses were measured at hourly intervals after cessation of heating. Regardless of the interval between heating episodes, within the limits studied, recurrent mitotic synchrony was observed at 6-hour intervals in the tumors, but not in the normal intestine.

^* Supported by Research Grant CA 05256 from the National Cancer Institute, U. S. Public Health Service.

Research Career Development Awardee (GM-K3-863), National Institutes of Health, U. S. Public Health Service; addressee for inquiries.

Received 7/20/64.