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Electrophoretic Studies on Some Types of Mammalian Tissue Cell

( Department of Radiotherapeutics, University of Cambridge, Cambridge, England)

The electrophoretic mobilities of several types of mammalian tissue cells and the electrokinetic changes following the action of acetaldehyde and neuraminidase have been measured. It was not possible to generalize in regard to the relationship of electrokinetic charge to type of cell, site of origin, rate of growth, or ‘malignancy’ of the parent tissue. Sialic acids were shown to be released from all types of tissue cell by neuraminidase, where adequate quantities of cells permitted chemical detection, irrespective of whether an appreciable decrease in mobility took place.

^* Present address: Department of Biochemistry, University of Southern California, Los Angeles 33, Calif.

Received 5/ 6/64.