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Transplantation of Spontaneously Occurring and Chemically Induced Lymphoid Tumors in Xenopus laevis^*

( Station for Experimental Zoology, University of Geneva, Chêne Bougeries, Geneva, Switzerland)

Two spontaneous and three methylcholanthrene-induced lymphoid tumors in the anuran amphibian Xenopus laevis laevis were transferred into the dorsal lymph sac, abdominal cavity, or under the abdominal skin of 93 immature or adult animals of the same species. Eighty-eight gave positive results, 76 with the persistence of the tumor at the implantation site and 70 with the development of visceral tumors, particularly in the liver, kidneys, and spleen. The development of the visceral tumors is discussed in terms of their possible origin from implanted tumor cells (metastasis) or host cells (host cell transformation).

^* This work is supported by the Fonds national suisse pour la recherche scientifique (No. 2219).

Received 6/19/63.

This article has been cited by other articles:

				L. N. Ruben and M. Balls Genetic Disparity and Cancer Induction by Normal Tissue Implants in Amphibia Science, December 4, 1964; 146(3649): 1321 - 1322. [Abstract] [PDF]