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The Induction of Mammary Cancer in Male Mice by Isologous Pituitary Implants^*

( Department of Anatomy, University of Alberta, Edmonton, Alberta, Canada)

Hybrid (C3H/A) male mice which had received isologous pituitary implants developed mammary tumors. Since the incidence of spontaneous tumors in these mice is extremely low, the fact that thirteen out of 47 (27 per cent) mice given implants developed mammary tumors is highly significant. The histology was comparable to that found in corresponding tumors in the female.

^* This work was supported by a grant from the National Cancer Institute of Canada. This work was begun by Dr. H. E. Rawlinson, who was unable to complete it owing to ill health.

Received 6/26/63.