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Augmentation of 6-Aminonicotinamide Antagonism of Tumor Growth by Compounds with Estrogenic Activity^*

( Department of Biochemistry, University of Miami, School of Medicine, Miami, Florida)

The hormonal derivatives diethylstilbestrol, hexestrol, dienestrol, cortisone, estradiol-17, estradiol-17ß, progesterone, and phloretin were compared with regard to their capacity to enhance carcinostasis in the presence of the niacin antagonist 6-aminonicotinamide. Diethylstilbestrol and hexestrol were found to be more powerful than either estradiol-17ß or dienestrol. Phloretin, estradiol-17, and progesterone were without activity.

Cortisone, either alone or in the presence of 6-aminonicotinamide, exhibited slight antitumor activity.

In the absence of 6-aminonicotinamide, diethylstilbestrol, hexestrol, dienestrol, and estradiol-17ß had no antitumor activity.

The suggestive correlation between estrogenic activity and enhancement of carcinostasis in the presence of 6-aminonicotinamide is discussed.

^* This work was supported in part by Grant CY-4868 and a Career Development Award GM-K3-15, 186 from the United States Public Health Service.

Received 7/ 5/63.