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Virus-like Particles in the Cells of Lymphoma 6C3HED^*

( New York Hospital-Cornell Medical Center, Department of Pathology, New York, New York)

A spherical, virus-like particle 60–100 mµ in diameter in the cytoplasm of cells of Lymphoma 6C3HED is described. It has a dense, double, outer shell and a more lucent core. It appears to arise at the membranes of the endoplasmic reticulum by a budding process and, once formed, is seen only within the confines of the cisternae. The morphology of the particle conforms with Bernhard's type A virus, which has been found in a variety of spontaneous and induced, transmissible and transplantable murine neoplasms.

^* Supported in part by American Cancer Society Grants and United States Public Health Service Grants.

Received 7/ 5/63.