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[Cancer Research 24, 212-216, February 1, 1964]
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Oncolysis by Clostridia. I. Activity of Clostridium Butyricum (M-55) and Other Nonpathogenic Clostridia against the Ehrlich Carcinoma

J. R. Möse and G. Möse

(The Institute for Hygiene, University of Graz, Austria)

Intravenous injections of suspensions of spores of Cl. butyricum (Strain M-55) produced a more or less extensive lysis of tumor tissue. A number of other strains of nonpathogenic clostridia did not show substantially improved results. In genreal, strains which were able to ferment carbohydrate performed equally well, whereas primarily proteolytic strains gave inferior results. Combination of Strain M-55 with Cl. felsineum, as well as a combination of Strain M-55 with culture filtrates of Cl. paraputrificum, did not yield improved results. All growth phases of Cl. butyricum could at least in principle produce the phenomenon of oncolysis, but the results were most unfavorable if vegetative forms were used. To some extent an enhancement of oncolysis could be obtained by a combination of spores with certain tumor extracts.

Received 6/16/63.


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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Cell Growth & Differentiation
Copyright © 1964 by the American Association for Cancer Research.