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4-Nitroquinoline N-Oxide: An Inhibitor of Benzpyrene Carcinogenesis of Mouse Skin^*

( Cancer Research Laboratories, Department of Pathology, The Medical School, Birmingham, England)

The rate of appearance of papillomas on the skin of mice treated with 3,4-benzpyrene was markedly retarded by 4-nitroquinoline N-oxide, applied either in the same solution as the benzpyrene or 3 days before each benzpyrene application. Carcinogenesis by 1,2,5,6-dibenzanthracene was also inhibited. No inhibition was observed when the nitroquinoline oxide and benzpyrene were applied to separate sites on the mice. The significance of the results is discussed with regard to the toxicity of 4-nitroquinoline N-oxide and the known inhibition of skin carcinogenesis by other agents which interact with sulfhydryl groups.

^* Supported by the Birmingham Branch of the British Empire Cancer Campaign.

Received 7/ 9/63.