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The Effect of Parathyroid and Other Human Tumors and Tissues on Bone Resorption in Tissue Culture^*

( Department of Oral Histopathology and Periodontology, Harvard School of Dental Medicine; the James Homer Wright Pathology Laboratories, Massachusetts General Hospital; and the Department of Pathology, Harvard Medical School, Boston, Mass.)

Mouse calvaria were grown in tissue culture in combination with single or multiple fragments of a variety of human tumors and glandular tissues to determine their capacity to enhance bone resorption. Single fragments of parathyroid adenoma tissue consistently enhanced resorption in both the frontal and the parietal bones. Except for one squamous-cell carcinoma of the lung which had some activity all other tissues tested as single fragments had no enhancing effect. On the other hand, all human tissues enhanced resorption when multiple fragments were placed in a halo around the calvarium, suggesting the presence of lesser amounts of resorption-enhancing factors in other human tissues.

^* This work was supported in part by grants C-3695, C-3424, and DE 01298 from the National Cancer Institute and the National Institute of Dental Research, U. S. Public Health Service.

Received 7/22/63.