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Deposition of Benzo[a]pyrene in Mouse Fat after Oral Administration^*

( Biological Station, Roswell park Memorial Institute, N. Y. State Dept. of Health, Springville, N. Y.)

Deposition of orally administered benzo[a]pyrene (BP) in the adipose tissue (and therefore the mammary gland) of mice depended upon the type of solvent, the concentration of BP in the test meal, and upon the genetic constitution of the test animal; the presence or absence of a gall bladder did not affect the amount of BP taken up by the fat. When the volume of a 1 per cent BP in olive oil meal was varied from 0.05 to 0.4 ml., the concentration of BP in the fat increased only up to a limit reached when 0.15 ml. of solution was fed. Trioctanoin was less effective than olive oil as a solvent. In most strains there was no difference between Tween 60 and olive oil, but in C57/St mice Tween 60 was a more effective solvent. The 22 stocks of mice that were studied could be divided into two groups, those giving high levels of BP in the fat and those giving low levels. This grouping followed a pattern consistent with the genetic origin of these stocks. In four strains there was a significant effect of sex on the deposition of BP in the fat. It is suggested that some of the differences among mice of different sexes and strains were due to differences in the body weight.

^* This investigation was supported in part by PHS grant # CA-04632 from the National Cancer Institute, Public Health Service.

Received 8/10/63.