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A Study of the Leukemoid Response to Transplantable A-280 Tumor in Mice^*

( Department of Medicine, University of Kentucky Medical Center, Lexington, Kentucky)

A preliminary study of the characteristics of the leukemoid response to transplantable A-280 tumor in BALB/c and B6D2 F₁ mice is presented. A direct correlation between the magnitude of leukemoid response and the duration of tumor implant was noted. Liver, kidney, spleen, and adrenals of leukemoid tumor-bearing animals showed an increase in weight which was correlated with myelogenous cellular infiltration. The excision of tumor resulted in a disappearance of the leukemoid response and return of spleen weight to normal. In investigating the mechanism of the leukemoid response various tumors and tissue homogenates were injected subcutaneously in an attempt to provoke a similar type of response. A leukemoid response similar to that in tumor-bearing animals was found only with the injection of fresh tumor homogenate.

Electrophoresis of serum from leukemoid tumor-bearing animals revealed abnormal components in the _{1 2}, and fractions, which increased with duration of tumor growth and leukocyte response. A concept of a factor present in, or elaborated by, tumor cells that induces myelopoiesis directly or through enhancement of physiological mechanisms is discussed.

^* This investigation was supported by Grant No. CA06490-01 from the National Cancer Institute, National Institutes of Health, United States Public Health Service.

Received 8/19/63.

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